A novel method to characterize genes with high-precision in single cells
The analysis of gene products in cells is an important tool for diagnosing disease and the design of new active …
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Pain and gain: Skin nerves anticipate and fight infection
Pinch yourself. If you feel pain, it’s thanks to specialized nerve endings in the skin. And, in a surprising discovery, …
Living longer or healthier? Genetic discovery in worms suggests they can be separated
Aging research indicates that better healthspan — the quality of life as we age — may be more important than …
DNA replication machinery captured at atom-level detail: Scientists reveal a crystal structure that illustrates a mechanism that powers and possibly starts DNA replication
Life depends on double-stranded DNA unwinding and separating into single strands that can be copied for cell division. St. Jude …
Researchers discriminate between mutations that promote cancer growth and those that don’t
Until now, researchers believed recurrent mutations (hotspot mutations) in cancer tumors were the important mutations (driver mutations) that promoted cancer …
Tracking life’s first step: Two molecules ‘awaken’ brand new genome
Within hours after fertilization, a unique genome forms from chromosomes contributed by the egg and sperm. However, this new genome …
A new mechanism for accessing damaged DNA
UV light damages the DNA of skin cells, which can lead to skin cancer. But this process is counteracted by …
Spatial DNA organization forms first, then the rest
The fundamental organization of the DNA in active and inactive compartments arises immediately after fertilization of the oocyte, even before …
Creating a global map of the protein shape universe: Novel mapping technique opens the door to new insights about functions in the body
Proteins can provide a detailed look inside the human body and how it protects itself from many diseases. Proteins, which …
Proofreading the book of life: Gene editing made safer
The advance of science is something like the wandering of an explorer through an uncharted jungle. Often, the dense undergrowth …
Slug glue reveals clues for making better medical adhesives: Findings could lead to suture alternatives that are flexible and strong
The Dusky Arion slug produces a defensive glue that fouls the mouthparts of any would-be predator. Two new studies reveal …
Introducing a kinder, gentler way to blow holes in cells: For injecting CRISPR-Cas9 into cells, new technique is more efficient, simpler and cheaper
When scientists attempt to slip big molecules, like the Cas9 enzyme that is key to CRISPR gene editing, into cells, …
Designer organelles bring new functionalities into cells: Scientists create membraneless organelle to build proteins in living cell
For the first time, scientists have engineered the complex biological process of translation into a designer organelle in a living …
Key differences between prokaryotic and eukaryotic RNA silencing Argonaute enzyme unveiled
Enzymes have clearly defined active sites to allow the substrate molecule to fit intricately. This is often coupled with an …
New machine learning technique rapidly analyzes nanomedicines for cancer immunotherapy: Novel approach will aid scientists in optimizing SNAs as therapeutic vaccines to treat cancer
With their ability to treat a wide a variety of diseases, spherical nucleic acids (SNAs) are poised to revolutionize medicine. …
Folliculin mutations disrupt embryo implantation: Folliculin gene defects are implicated in some forms of infertility, certain cancers and other cell growth disorders
New information is unfolding on the genetic controls of an early turning point in pregnancy. As the tiny, dividing cell …