Rheumatoid arthritis tied to higher risk for aortic stenosis

Rheumatoid arthritis (RA) is associated with a higher risk for developing aortic stenosis, according to a study published online July 31 in JAMA Internal Medicine.

Tate M. Johnson, M.D., from the VA Nebraska-Western Iowa Health Care System in Omaha, and colleagues examined the risk for incident aortic stenosis, aortic valve intervention, aortic stenosis-related death, and risk factors for aortic stenosis in patients with RA. The analysis included 73,070 patients with RA and 639,268 matched controls without RA.

The researchers found that the aortic stenosis incidence rate was 3.97 per 1,000 person-years in patients with RA versus 2.45 per 1,000 person-years in control patients (absolute difference, 1.52 per 1,000 person-years). There was an increased risk observed for composite aortic stenosis with RA (adjusted hazard ratio, 1.48), as well as for aortic valve intervention (adjusted hazard ratio, 1.34) and aortic stenosis-related death (adjusted hazard ratio, 1.26).

“Findings of this study suggest that RA is associated with a higher risk of developing aortic stenosis as well as the subsequent risks of aortic valve intervention and aortic stenosis-related death,” the authors write. “Future studies are needed to confirm whether valvular heart disease, specifically aortic stenosis, may be an overlooked cardiovascular disease complication in RA.”

Several authors disclosed financial ties to industry.

More information:
Tate M. Johnson et al, Aortic Stenosis Risk in Rheumatoid Arthritis, JAMA Internal Medicine (2023). DOI: 10.1001/jamainternmed.2023.3087

Journal information:
JAMA Internal Medicine

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